Prediction of Inclusion Evolution During Refining and Solidification of Steel: Computational Simulation and Experimental Confirmation

Metallurgical and Materials Transactions B - We developed a simulation model to predict inclusion transformation during the solidification of steel by linking the Ohnaka model with the FactSage...     

Photo-crosslinking: An Emerging Chemical Tool for Investigating Molecular Networks in Live Cells

Studying protein–protein interactions (PPIs) is useful for understanding cellular functions and mechanisms. Evaluating these PPIs under conditions as similar as possible to native conditions can be achieved using photo-crosslinking methods because of their on-demand ability to generate reactive species in situ by irradiation with UV light. Various fusion tag, metabolic incorporation, and amber codon suppression approaches using various crosslinkers containing aryl azide, benzophenone, and diazirines have been applied in live cells. Mass spectrometry and immunological techniques are used to identify crosslinked proteins based on their capture transient and context-dependent interactions. Herein we discuss various incorporation methods and crosslinkers that have been used for interactome mapping in live cells.     

Maternal Malnutrition Affects Hepatic Metabolism through Decreased Hepatic Taurine Levels and Changes in HNF4A Methylation

Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet-related alterations in metabolites and the biological pathway in male offspring at three months of age. Pregnant rats were exposed to 50% food restriction during the prenatal period or a 45% high-fat diet during the prenatal and postnatal periods. The male offspring exposed to food restriction and high-fat diets had lower birth weights than controls, but had a catch-up growth spurt at three months of age. Hepatic taurine levels decreased in both groups compared to controls. The decreased hepatic taurine levels in offspring affected excessive lipid accumulation through changes in hepatocyte nuclear factor 4 A methylation. Moreover, the alteration of gluconeogenesis in offspring exposed to food restriction was observed to a similar extent as that of offspring exposed to a high fat diet. These results indicate that maternal diet affects the dysregulation in hepatic metabolism through changes in taurine levels and HNF4A methylation, and predisposes the offspring to Type 2 diabetes and non-alcoholic fatty liver disease in later life.     

A Decentralized Bi-Level Fuzzy Two-Stage Decision Model for Flood Management

Flood, as a serious worldwide environment problem, can lead to detrimental economic losses and fatalities. Effective flood control is desired to mitigate the adverse impacts of flooding and the associated flood risk through development of cost-effective and efficient flood management decisions and policies. A bi-level fuzzy two-stage stochastic programming model, named BIFS model is developed in this study to provide decision support for economic analysis of flood management. The BIFS model is capable of not only addressing the sequential decision making issue involving the two-level decision makers, but also correcting the pre-regulated flood management decisions before the occurrence of a flood event in the two-stage environment. The probabilistic and non-probabilistic uncertainties expressed as probability density functions and fuzzy sets are quantitatively analyzed. The overall satisfaction solution is obtained for meeting the goals of the two-level decision makers by compromising, reflecting the tradeoffs among various decision makers in the two decision-making levels. The results of application of the BIFS model to a representative case study indicate informed decision strategies for flood management. Tradeoffs between economic objectives and uncertainty-averse attitudes of decision makers are quantified.     

γ-γ符合测量系统的新型前端读出电路研制

研制了一种新型前端读出电路，用于重离子治癌装置中符合测量原型系统的研究和测试。电路主要包括能量链、时间链和数据处理单元。能量链由截止频率7 MHz的抗混叠滤波器和模数转换器(ADC)组成，形成波形采样电路；时间链由高速比较器构成的定时甄别电路和时间数字转换器（TDC）组成；数据处理单元基于现场可编程门阵列(FPGA)设计实现。电路的线性度优于0.8%，噪声小于0.8 mV（RMS）。配合LaBr3单晶体条测试，能量分辨为4.5%（FWHM），在与LYSO晶体阵列配合测试时，位置映射散点图清晰。该前端读出电路性能优于CAMAC系统，具有较好的实际应用前景。     

D-limonene Inhibits Pentylenetetrazole-Induced Seizure via Adenosine A2A Receptor Modulation on GABAergic Neuronal Activity

Background: Epilepsy is a chronic neurological disorder characterized by the recurrence of seizures. One-third of patients with epilepsy may not respond to antiseizure drugs. Purpose: We aimed to examine whether D-limonene, a cyclic monoterpene, exhibited any antiseizure activity in the pentylenetetrazole (PTZ)-induced kindling mouse model and in vitro. Methods: PTZ kindling mouse model was established by administering PTZ (30 mg/kg) intraperitoneally to mice once every 48 h. We performed immunoblot blots, immunohistochemistry (IHC), and high-performance liquid chromatography (HPLC) analysis after the behavioral study. Results: An acute injection of PTZ (60 mg/kg) induced seizure in mice, while pretreatment with D-limonene inhibited PTZ-induced seizure. Repeated administration of PTZ (30 mg/kg) increased the seizure score gradually in mice, which was reduced in D-limonene (10 mg/kg)-pretreated group. In addition, D-limonene treatment increased glutamate decarboxylase-67 (GAD-67) expression in the hippocampus. Axonal sprouting of hippocampal neurons after kindling was inhibited by D-limonene pretreatment. Moreover, D-limonene reduced the expression levels of Neuronal PAS Domain Protein 4 (Npas4)-induced by PTZ. Furthermore, the adenosine A2A antagonist {"type":"entrez-protein","attrs":{"text":"SCH58261","term_id":"1052882304","term_text":"SCH58261"}}SCH58261 and ZM241385 inhibited anticonvulsant activity and gamma-aminobutyric acid (GABA)ergic neurotransmission-induced by D-limonene. Conclusion: These results suggest that D-limonene exhibits anticonvulsant activity through modulation of adenosine A2A receptors on GABAergic neuronal function.     

Wet abrasive wear behavior of WC-based cermet coatings prepared by HVOF spraying

In this study, three kinds of WC-based cermet coatings including WC–CoCr coating, WC–Ni coating and WC–Cr₃C₂–Ni coating were prepared by the high-velocity oxygen-fuel (HVOF) spraying process. Scanning electron microscopy (SEM), energy disperse spectroscopy (EDS) and Vickers hardness tester were used to analyze the microstructure and mechanical properties of these coatings. The WC–CoCr coating presented the highest average microhardness of 1205 HV_0.3, and then followed by the WC–Cr₃C₂–Ni coating (1188 HV_0.3) and the WC–Ni coating (1105 HV_0.3). The abrasive wear behavior of the WC-based coatings under the conditions of different applied loads and sediment concentrations were studied by a wet sand-rubber wheel tester. The results indicated that the abrasive wear loss rates of all the coatings increased with the increment of applied load or sediment concentration. In addition, the coatings with higher microhardness appeared to have higher abrasive wear resistance. The abrasive wear resistance of the WC-based coatings was 4–90 times higher than that of AISI 304 stainless steel under the same testing condition. The abrasive wear mechanism of the WC-based coatings was deduced to be the extrusion and removal of binder phases, as well as the fragmentation and peel-off of hard phases.     

One-pot foam-gelcasting/nitridation synthesis of high porosity nano-whiskers based 3D Si3N4 porous ceramics

Nano-whiskers based 3D Si₃N₄ porous ceramics (3D-NWSNPC) with high-porosity (about 91–93 %), low density (0.17–0.25 g/cm³), low thermal conductivity, and a certain degree of recoverability under cyclic compressive loading and reasonably strengths were prepared at 1423–1523 K via a one-pot foam-gelcasting/nitridation route using inexpensive commercial Si powders as starting materials and hexadecyl trimethyl ammonium bromide as foaming agent. After nitridation at 1523 K, the sample with an original solid loading of 12.5 wt% exhibited the highest compressive strength of 1.9 MPa, even though its density was lowered to 0.25 g/cm³. The sample nitrided at 1473 K had a relative density of 7.3 %. Its compressive and specific strength were respectively 1.1 MPa and 5.5 MPa·cm³ g^?1, and its thermal conductivity was as low as 0.074 W/(m K) (measured at 323 K). These outstanding properties would make the as-prepared 3D-NWSNPC a promising candidate for applications in catalysis, filtration, thermal insulation and many other important areas.     

透明超疏水涂层制备技术研究进展

透明超疏水涂层兼具独特的超疏水性及光学透明性,由于其有着优异的自清洁性能,它可广泛应用于生产生活中的诸多领域.在不同基材上如何构建透明的超疏水涂层有着十分重大的研究价值,本文阐述了近年来透明超疏水涂层的制备方法进展,总结了透明超疏水涂层存在的主要问题及其发展方向.